Biologics don’t suddenly lose potency — they’re damaged long before they reach your filters, sensors, or chromatography columns. The real culprit isn’t “shear stress” in the tubing; it’s what’s happening inside the pump. From cavitation and violent negative-pressure spikes to bubble collapse and hydrodynamic shock, traditional peristaltic and quaternary pumps are quietly hammering proteins every cycle. If your tubing is collapsing, your pump is screaming, or your mAbs are aggregating without explanation, you’re not dealing with a process issue — you’re dealing with pump-induced damage. In this article, we break down why the industry has normalised this and how Alphinity’s PIXER® pump eliminates the root cause with truly gentle, cavitation-free flow.

Major investment in Alphinity’s revolutionary single-use polymorphic pump technology based on shared goal of driving abundance in medicine.