VannX™ by Alphinity is a single-use, modular valve for upstream and downstream bioprocessing, featuring a compact design that integrates multiple valves into a polypropylene block for series, parallel, or custom configurations. Its radial geometry optimizes product capture, reducing hold-up volume for higher yields, with a TPE diaphragm and ultra-pure polypropylene body ensuring low extractables and broad chemical resistance. Offering gentler, precise flow control with lower shear than pinch valves, it’s vacuum-compatible and pressure-rated up to 6 bar/ 88 psi, delivering a scalable, robust solution for modern bioprocessing.

Only VannX Can

  • Deliver true motorized precision with 1000-step, ±0.05 bar/ 0.73 psi accuracy

  • Enable compact modular manifolds (Vannefold™)

  • Guarantee 100% single-use sterility no cleaning validation

  • Cut changeover times and campaign costs

  • Integrate seamlessly with Pharma 4.0 automation

Key Benefits

Positive Diaphragm Positioning: Exact control from -1.0 to 6.0 bar/ -14 to 88 psi.

Low Hold-Up Volume: Optimized geometry for maximum product recovery.

Robust Compatibility: PP + TPE construction resists fusing/swelling.

Ease of Use: Tool-free installation, visible position indicator, IP65 protection.

Application Versatility: Ideal for CGT, mAbs, biosimilars, and viral vectors

Vannefold™ takes single-use valve control beyond tubing assemblies. By integrating multiple VannX™ motorized diaphragm valves into a machined polypropylene block, it enables compact clusters in series, parallel, or custom flow paths. The result: a smaller footprint, lower hold-up volume, and simplified process design.

Engineered for continuous manufacturing and multi-day runs, Vannefold™ delivers the sterility, precision, and scalability today’s biopharma demands — from cell & gene therapy to monoclonal antibodies.

Key Benefits

Maximize Yield: Best in class center-to-center port designfor reduced internal fluid volume.

Compact Footprint: Integrates 2–5 VannX™ valves into one streamlined block.

Flexible Configurations: Supports series, parallel, or custom flow setups. Built for Continuous Manufacturing: Engineered for 60 day continuous processes, maintaining sterility and reliability.

Precise Control: 1000's-step motorized actuation with ±0.05 bar/ 0.73 psi accuracy

Positive Diaphragm Positioning: Exact control across -1.0 to 6.0 bar/ -14 to 88 psi.

Chemical Compatibility: PP + TPE construction resists swelling/fusing over long closure periods.

Seamless Integration: Fully compatible with VannX™ specs, including IP65 protection and automation interfaces.