VannX™ & Vannefold™

Single-Use Motorized Diaphragm Valves for Bioprocessing

A scientific valve labeled 'VannX' with a black actuator and white body, used for controlling fluid flow.

Key Benefits

  • Disposable fluid path (valve body + diaphragm)

  • Reusable high-precision motorized actuator (24 V DC)

  • No compressed air required

  • Ultra-precise control (±0.05 bar) with 1800-step resolution

  • Best-in-class low hold-up volume & maximized product yield

  • Optimized internal geometry prevents swelling-induced closures

  • Compact footprint — especially with Vannefold™ multi-valve blocks

  • Robust chemical compatibility (PP + TPV + EPDM)

  • Tool-free installation with visible position indicator

  • Engineered for continuous processing (reliable 60-day campaigns)

  • Pharma 4.0 ready — encoder feedback, IP65, M12 connectivity

VannX™ vs. Vannefold™ – What’s the Difference?

VannX™ is the individual motorized diaphragm valve. It consists of one disposable valve body (wetted fluid path) and one reusable high-precision motorized actuator. Each VannX™ provides accurate, repeatable flow control at a single point in your process.

Vannefold™ is a compact valve block that integrates 2–5 VannX™ valves into a single machined polypropylene unit. The valve bodies are molded or machined directly into the block, creating very short internal flow paths, minimized center-to-center port spacing, and significantly lower hold-up volume than individual valves connected with tubing and fittings. Each valve position still has its own reusable actuator.

In short:

  • Use VannX™ for single-point control (one valve in a line, bypass, inlet/outlet, etc.)

  • Use Vannefold™ when you need multiple valves close together (manifolds, multi-way flow paths, series/parallel setups, perfusion circuits, chromatography skids)

Both share the same core advantages: disposable fluid path, reusable precision actuator, no pneumatics, low hold-up, and excellent chemical compatibility.

Next-generation single-use diaphragm valves purpose built for modern bioprocessing

VannX™ is a compact, motorized diaphragm valve that brings exceptional control and efficiency to downstream biopharmaceutical applications.

It delivers ultra-precise, repeatable diaphragm positioning — enabling very tight control of transmembrane pressure (TMP), flow rates and back pressure that today’s sensitive biologics require. The optimized internal geometry significantly reduces hold-up volume, enhances complete product recovery and prevents unwanted closures from chemical swelling — even at high concentrations.

The fluid-contact path (valve body and diaphragm) is fully single-use — ensuring sterility and eliminating cross-contamination risk — while the compact, reusable 24 V DC motorized actuator removes the need for compressed air infrastructure entirely.

Fully automation-ready and Pharma 4.0 compatible (encoder feedback, IP65 protection, M12 connectivity), VannX™ integrates seamlessly into modern control systems.

Compared to traditional pinch valves, VannX™ and Vannefold™ offer cleaner flow geometry, dramatically lower hold-up volume, higher product yield, consistent performance without tubing fatigue, and complete elimination of compressed air systems — all while maintaining full compatibility with single-use workflows.

A Vannefold diaphragm electric valve block, metallic body, and white plastic fittings, labeled 'Vannefold'.
Diagram of a Valves with sections for electric diaphragm, electric pinch, manual pinch, check valve, and pneumatic pinch, including descriptions of features and capabilities.

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Single-Use Diaphragm Valve Technical Data Sheet

Frequently Asked Questions

  • VannX™ is a single-use, motorized diaphragm valve designed for precise, sterile fluid control in biopharmaceutical manufacturing.
    It uses high-resolution motor actuation to deliver stable, repeatable flow and pressure control while eliminating the need for compressed air or reusable actuators.

  • Unlike pneumatic or hybrid motorized valves, VannX™ is fully single-use, including the actuator — removing cleaning, sterilisation, and revalidation requirements.

    It combines:

    • Compact, low-profile geometry

    • High-precision motor control (thousands of steps)

    • 24 V DC operation (no compressed air)

    • Automation-ready encoder feedback

    This results in smaller systems, better control, and simpler validation.

  • VannX™ delivers fine, repeatable modulation of flow and pressure, supporting applications that require tight control rather than simple open/close functionality.

    High-resolution motor control enables stable operation across sensitive process steps, including pressure-critical filtration and low-shear flow paths.

  • Yes. VannX™ is designed as a drop-in replacement for standard tubing and manifold assemblies.

    It supports:

    • Hose barb and clamp connections (ASME-BPE compatible)

    • Standard M12 electrical connectors

    • Integration with existing skid and automation architectures

    No system re-engineering is required.

  • VannX™ is available in sizes ranging from 1/8” to 1” (DN 3–25) and supports both vacuum and positive pressure operation.

    Its internal geometry and diaphragm materials are optimised to minimise hold-up volume while maintaining durability and chemical compatibility.

  • VannX™ is designed for global biopharmaceutical manufacturing and meets key industry requirements, including:

    • FDA compliance

    • USP Class VI biocompatibility

    • BSE/TSE free materials

    • ISO Class 7 cleanroom assembly

    • Lifecycle validation for high-cycle operation

    This makes it suitable for clinical and commercial GMP environments.

  • VannX™ helps teams achieve:

    • Improved product recovery through reduced dead volume

    • Gentler handling of shear- and cavitation-sensitive biologics

    • Simplified changeovers with no cleaning or sterilisation steps

    • More stable automation and control performance

  • VannX™ is well suited for applications including:

    • Cell and gene therapy manufacturing

    • Monoclonal antibody (mAb) processing

    • Viral vector and vaccine production

    • Biosimilars and high-value biologics

    Anywhere precision flow control and sterility are critical.

  • By eliminating compressed air, reusable actuators, and cleaning validation, VannX™ can deliver:

    • Faster changeovers

    • Higher effective throughput

    • Reduced operating and energy costs

    • Smaller cleanroom footprint

    For many users, these gains allow VannX™ to pay for itself over the system lifecycle.

  • VannX™ is designed for:

    • Biopharma manufacturers scaling from clinical to commercial

    • CDMOs seeking faster turnaround and higher utilisation

    • CGT innovators protecting high-value products

    • Engineering and operations teams focused on reducing CoGs