About Alphinity

Enabling Abundance In Medicine™

About Alphinity

Alphinity is a bioprocessing technology company focused on precision flow control for modern biologics manufacturing. We design and deliver advanced pumps, valves, systems, and control platforms that help biopharmaceutical teams build processes that are predictable, scalable, and efficient from process development through GMP manufacturing.

Our work sits at the intersection of fluid handling, automation, and process behaviour, informed by a team of engineers with decades of experience designing and implementing flow control technologies in regulated environments. This includes the integration of Aquasyn, a specialist valve manufacturer with over 30 years of experience in high-performance valve design, bringing proven engineering heritage into Alphinity’s platform.

By combining deep component-level expertise with system-level design, Alphinity operates as a solutions provider — addressing recurring bioprocessing challenges through configurable, application-driven systems rather than isolated components. This approach allows small improvements in control behaviour to translate into meaningful gains in yield, quality, and time to market.

The Challenges Facing Modern Bioprocessing

Despite major advances in drug discovery, many biopharmaceutical manufacturing processes remain difficult to scale and automate reliably. Existing production technologies are often not agile or efficient enough to support modern manufacturing models, resulting in workflows that require constant tuning, rework, and manual intervention.

These limitations make it difficult for companies to move processes from development to GMP, adopt modular or distributed manufacturing strategies, or operate efficiently across varying production volumes. In practice, this shows up as a consistent set of challenges across development and manufacturing.

Bioprocessing Challenges We Address

Alphinity focuses on solving the recurring, system-level challenges that limit performance and scalability in bioprocessing environments:

  • Variability and instability caused by inconsistent flow control and unpredictable component behaviour

  • Automation systems that rely on tuning and manual intervention rather than engineered, repeatable behaviour

  • Scaling processes from process development to GMP without rework, requalification, or loss of control

  • Shear and cavitation risks that can compromise biologic integrity and effective potency in sensitive processes

  • Regulatory and validation complexity that increases burden and slows deployment of new workflows

  • Extended time to market driven by repeated optimisation and process correction cycles

  • Limited flexibility of standardised solutions in complex or evolving bioprocessing applications

  • Sustainability pressures across single-use systems and fluid handling operations, including waste and resource efficiency

Our Approach

Alphinity approaches these challenges through the lens of flow behaviour and control. Rather than treating pumps, valves, and systems as discrete pieces of hardware, we design platforms that function as behavioural control elements within the process.

This philosophy enables bioprocessing teams to move from managing variability to engineering precision into their workflows. By focusing on how components behave under real process conditions — across flow ranges, pressures, and operating modes — we help teams build processes that perform consistently as they scale.

Our solutions are designed to:

  • Support precise, low-shear fluid handling that protects the structural integrity of the most sensitive biologics

  • Preserve effective potency through design, by minimising shear, cavitation, and uncontrolled flow conditions that can degrade product quality

  • Enable scalable workflows from bench-scale development to commercial GMP manufacturing

  • Reduce validation burden through stable, repeatable, and predictable component behaviour

  • Integrate seamlessly with automation, sensing, and analytical systems to support modern control strategies

Precision Flow Control for Modern Manufacturing

At the core of Alphinity’s portfolio are technologies engineered to deliver controlled, homogeneous flow across a wide range of operating conditions. Our solutions support multiple unit operations — including mixing, dilution, filtration, and transfer — while maintaining the control fidelity required for sensitive biologic processes.

Through flexible system configurations, integrated sensing, and compatibility with advanced control platforms, Alphinity solutions support Quality by Design (QbD) strategies and modern automation frameworks aligned with Pharma 4.0 principles.

Why It Matters

More than two billion people globally still face limited access to essential medicines. Addressing this challenge requires manufacturing technologies that are not only innovative, but practical, scalable, and efficient.

By improving flow control, reducing process inefficiencies, and enabling adaptable manufacturing models, Alphinity aims to help biopharmaceutical companies produce more medicines, more reliably — and bring them to patients faster.

Professional Associations