The Manufacturability Gap
New therapies are failing in manufacturing, not in the lab. Fragile modalities. Viscous formulations. Unstable TMP. Scale-up failure. Alphinity designs the fluid handling systems that solve these problems at the source.
Enabling Abundance in Medicine™. Precision fluid handling for the therapies that matter most.
Process-First Engineering
Every piece of Alphinity equipment is designed around a specific process challenge. Four territories where conventional fluid handling consistently fails, and where our technology makes the difference.
Viral vectors, cell therapies, exosomes, LNPs. Standard processing loses 20 to 40% of AAV titer to mechanical damage. Our single-use diaphragm pump eliminates the root cause: positive displacement with no product contact with moving parts.
High-concentration mAbs, dense biologics, viscous buffers, and intensified processes. Conventional pumping technologies cannot maintain reliable flow above ~500 cP. Our diaphragm pump handles up to 3,000 cP with flow rate independent of viscosity and backpressure.
Unstable transmembrane pressure leads to membrane fouling, inconsistent flux, and failed batches. Near-pulseless diaphragm pumping combined with our electric diaphragm valve delivers the precision-controlled flow that sensitive processes demand.
Processes that work at bench scale fail in manufacturing because the mechanical conditions change with scale. Alphinity's platform maintains identical flow behavior from 30 mL screening to 10 L clinical batches. No process redesign.
The same TFF skid that works for monoclonal antibodies will tear apart a viral vector. Alphinity equipment is engineered around the modality being made, not the modality biopharma made twenty years ago.
TFF that preserves capsid integrity. Pump architecture that does not shear what it carries. Single-use end to end.
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Sterile filtration, concentration, and buffer exchange engineered around the chemistry and the stability window mRNA actually has.
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Concentration and TFF without compromising the lipid bilayer. Shear and pulsation managed at the architecture level.
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Small-batch, closed-system compatible, autologous-friendly. Built for the scales gene therapy actually runs at.
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Single-use TFF, low-shear pumping, and process equipment for recombinant proteins and monoclonal antibodies at every scale.
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Upstream of viral vector and mRNA. TFF and filtration for GMP plasmid production at the scale and purity downstream programs depend on.
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Each product solves a specific manufacturing problem. They work independently, and together as an integrated platform.
Flagship system
Tangential flow filtration for sensitive biologics. Ultra-low shear pumping. 30 mL to 10 L. Fully automated.
Pump Technology
Positive displacement. Ultra-low shear, near-pulseless flow. Handles viscous fluids where peristaltic pumps fail.
Valve Technology
±0.3 PSI precision, continuously adjustable via microstepping. 24V DC electric. No compressed air required.
Pinch Valve Series
Motorized, pneumatic, and manual pinch valves. Clamp-on design, visible position indicator, compatible with all standard single-use tubing.
Explore ARTēVA® ›
Process Safety
Prevents backflow and protects process integrity. Available in multiple port configurations for inline integration across tubing sizes.
Explore SoloCheck™ ›
Fluid Handling
Inline buffer dilution that replaces large-volume buffer prep tanks. Closed-system, single-use, designed for the footprint and flexibility modern facilities actually run on.
Explore Buffer DilutionThe Fundamentals Hub
Process science from the Alphinity engineering team. Plain English explanations of why fluid handling matters as much as the molecule it carries, organized by the three areas where the questions keep coming back.
Shear, cavitation, pulsation, and dead volume. The four failure modes that legacy pump designs amplify and what positive displacement architecture solves.
Explore pump science ›Diaphragm versus pinch versus check. Actuation precision, closed-system compatibility, and the configurations that matter for fragile-modality fluid handling.
Explore valve engineering ›Membrane selection, crossflow rate, TMP control, fluid path geometry. The full design conversation for TFF that holds capsid integrity, not just retention.
Explore TFF science ›Bespoke Systems
Standard systems force your process to adapt to the equipment. We start with your process constraints (flow behavior, pressure sensitivity, viscosity, scale) and engineer a system that fits. PIXER® pumps, VannX™ valves, and ConSynSys™ automation as building blocks.
Alphinity × Aquasyn
Alphinity sits in the single-use half of bioprocessing. Aquasyn is the stainless steel sister brand. The same engineering team designs both. For teams running hybrid lines, that means one design conversation across both modalities instead of two suppliers.
Built to the standards that matter
In the industry
Alphinity is active across the global bioprocessing community. The conferences where the industry's process challenges are discussed and solved.
Get Started
Start with a datasheet, or talk directly to our process engineers. We'll help you find the right approach for your application.