The Manufacturability Gap
New therapies are failing in manufacturing — not in the lab. Fragile modalities. Viscous formulations. Unstable TMP. Scale-up failure. Alphinity designs the fluid handling systems that solve these problems at the source.
Enabling Abundance in Medicine™ — precision fluid handling for the therapies that matter most
Process-First Engineering
Every piece of Alphinity equipment is designed around a specific process challenge. Four territories where conventional fluid handling consistently fails — and where our technology makes the difference.
Viral vectors, cell therapies, exosomes, LNPs. Standard processing loses 20–40% of AAV titer to mechanical damage. Our single-use diaphragm pump eliminates the root cause — positive displacement with no product contact with moving parts.
High-concentration mAbs, dense biologics, viscous buffers, and intensified processes. Conventional pumping technologies cannot maintain reliable flow above ~500 cP. Our diaphragm pump handles up to 3,000 cP with flow rate independent of viscosity and backpressure.
Unstable transmembrane pressure leads to membrane fouling, inconsistent flux, and failed batches. Near-pulseless diaphragm pumping combined with our electric diaphragm valve delivers the precision-controlled flow that sensitive processes demand.
Processes that work at bench scale fail in manufacturing because the mechanical conditions change with scale. Alphinity's platform maintains identical flow behavior from 30 mL screening to 10 L clinical batches — no process redesign.
The same TFF skid that works for monoclonal antibodies will tear apart a viral vector. Alphinity equipment is engineered around the modality being made, not the modality biopharma made twenty years ago.
TFF that preserves capsid integrity. Pump architecture that does not shear what it carries. Single-use end to end.
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Sterile filtration, concentration, and buffer exchange engineered around the chemistry and the stability window mRNA actually has.
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Concentration and TFF without compromising the lipid bilayer. Shear and pulsation managed at the architecture level.
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Small-batch, closed-system compatible, autologous-friendly. Built for the scales gene therapy actually runs at.
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Single-use TFF, low-shear pumping, and process equipment for recombinant proteins and monoclonal antibodies at every scale.
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Upstream of viral vector and mRNA. TFF and filtration for GMP plasmid production at the scale and purity downstream programs depend on.
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Each product solves a specific manufacturing problem. They work independently — and together as an integrated platform.
Flagship system
Tangential flow filtration for sensitive biologics. Ultra-low shear pumping. 30 mL to 10 L. Fully automated.
Pump Technology
Positive displacement. Ultra-low shear, near-pulseless flow. Handles viscous fluids where peristaltic pumps fail.
Valve Technology
±0.3 PSI precision, continuously adjustable via microstepping. 24V DC electric — no compressed air required.
Pinch Valve Series
Motorized, pneumatic, and manual pinch valves. Clamp-on design, visible position indicator, compatible with all standard single-use tubing.
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Process Safety
Prevents backflow and protects process integrity. Available in multiple port configurations for inline integration across tubing sizes.
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Fluid Handling
Inline buffer dilution that replaces large-volume buffer prep tanks. Closed-system, single-use, designed for the footprint and flexibility modern facilities actually run on.
Explore Buffer DilutionProcess Expertise
Most bioprocess problems are blamed on chemistry — buffer formulation, cell line, upstream conditions. In our experience, the failure is often mechanical. The physics of how fluid is moved matters as much as what's in it.
Understanding the failure modes is how we design equipment that doesn't cause them.
Most bioprocess pumping technology was engineered for water and chemical transfer — not sensitive biologics. The mechanical principles that make them work (compression, rotor contact, pulsation) are fundamentally incompatible with fragile proteins and viral particles. The damage is cumulative, often invisible, and inherent to the design — not a flaw that can be tuned away.
When a pump creates negative pressure at its inlet, dissolved gases form bubbles that collapse violently — generating forces that destroy proteins and viral particles at the molecular level.
Because the mechanical conditions change. Different pump, different flow profile, different pressure dynamics. Physical process continuity matters as much as the recipe.
Bespoke Systems
Standard systems force your process to adapt to the equipment. We start with your process constraints — flow behavior, pressure sensitivity, viscosity, scale — and engineer a system that fits. PIXER® pumps, VannX™ valves, and ConSynSys™ automation as building blocks.
Built to the standards that matter
In the industry
Alphinity is active across the global bioprocessing community. The conferences where the industry's process challenges are discussed and solved.
Get Started
Start with a datasheet, or talk directly to our process engineers. We'll help you find the right approach for your application.