SoloCheck™ Single-Use Check Valve
An advanced single-use non return valve, engineered for reliable one-way flow control and passive backflow prevention in high-purity biopharmaceutical and bioprocessing systems. Specifically designed to protect sensitive biologics, cell and gene therapies, mRNA, vaccines, monoclonal antibodies, and other shear-sensitive fluids, SoloCheck™ delivers exceptional performance in sterile, disposable workflows.
Its innovative diaphragm-based design, no springs, no metal components, no complex mechanisms—provides a clean, straight-through flow path that delivers:
Very low cracking pressure — opens gently to minimize shear stress and pressure spikes, protecting fragile biologics and living cells
Minimal pressure drop — maintains excellent flow efficiency, reduces system resistance, and supports gentle handling of high-value products
Secure, reliable reverse-flow sealing — prevents backflow, contamination, cross-contamination, and potential damage to upstream filters, pumps, chromatography columns, and other critical process components
Key advantages include:
Gamma-irradiation stable — fully compatible with standard gamma sterilization protocols (up to 50 kGy)
Ultra-pure materials — an exceptional extractables profile to support product purity and regulatory compliance
Straightforward, unobstructed flow path — reduces hold-up volume and simplifies cleaning validation
Broad chemical compatibility — resistant to typical bioprocess buffers, media, acids, bases, and sanitizing agents
Compact and lightweight — easy to integrate into tubing sets, manifolds, single-use bioreactors, and space-constrained assemblies
Common applications:
Downstream protection in pumping and transfer lines
Prevention of cross-contamination in multi-path systems
Perfusion circuits, filtration setups, media and buffer transfer, final fill & finish lines, viral inactivation workflows, and more
Choose SoloCheck™ for dependable, sterile, single-use backflow protection that safeguards biologics integrity, improves process consistency, reduces equipment stress, simplifies validation, and supports high-yield, high-quality biomanufacturing.