The 2025 ISPE Pharma 4.0™ Conference will bring together leading pharmaceutical and biopharmaceutical manufacturers, technology providers, academic scientists, and international regulators to network, share insights, and provide an outlook on digital transformation, automation, and the evolving landscape and future of Pharma 4.0™. Pharma 4.0 is a holistic end-to-end implementation of digitalization across all stages of project execution, manufacturing, and regulatory processes and along the pharmaceutical supply chain. The key challenges of drug shortages and drug availability can be tackled by the increasing support and impact of innovative enabling technologies, such as artificial intelligence (AI), machine learning (ML), virtual and augmented reality, IIoT, Gxp Cloud & low code platforms, robotics, advanced modeling and automation. Digital transformation is significantly advancing pharmaceutical quality as it builds the foundation for the Quality by Design and process understanding approach to manage the holistic control strategy concept based on an accurate data management and well understood and controlled process models.