Flow Control Fundamentals

Understanding the physics behind the process.

Pump architecture determines shear. Valve response determines control. System design determines yield. We publish what we've learned — because better engineering decisions start with better understanding.

Pump Science — bioprocessing pump mechanics
Pump Science
How pump architecture shapes product integrity
  • Peristaltic vs diaphragm vs centrifugal
  • Cavitation, NPSH, and why your pump makes noise
  • Pulsation and harmonic resonance
  • Viscosity — why flow collapses above 500 cP
  • Particle shedding and contamination
Explore pump science →
Valve Engineering — bioprocess valve selection
Valve Engineering
Why valve response matters more than valve type
  • Pneumatic vs electric actuation
  • Pressure control accuracy — what ±0.3 PSI means
  • Continuous positioning vs binary open/close
  • Compressed air elimination
  • Predictive maintenance from actuator data
Explore valve engineering →
TFF and Filtration — tangential flow filtration
TFF & Filtration
The equipment variables that determine TFF yield
  • Where TFF yield loss actually comes from
  • TMP stability and pulsation
  • Scale-up failure — why bench results don't transfer
  • Working volume — the silent yield killer
  • Membrane agnostic vs vendor lock-in
Explore TFF science →

Built on 30 years of bioprocess engineering

Alphinity's team has designed fluid handling systems for biopharmaceutical manufacturing since the mid-1990s — from stainless steel valve fabrication through single-use chromatography systems to the next generation of pumps and automation.

30+
Years in bioprocess engineering
6
Patents in fluid handling
ISPE NIIMBL BPSA
Industry memberships
7
Product families

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